Lab life

May 6, 2016 – Evgeni’s Wedding

Congratulations Evgeni and Chen!



















March 22, 2016

Purim: Our lab has exploded!












February 23, 2016

Sheli’s new paper is out. In this paper we collaborated with Molecular Pathologist Dov Hershkovitz (extra perks of the collaboration included a tour of his specimen buckets which will not be easily forgotten). We examined the distribution of KRAS driver substitutions among patients with lung, colon and pancreatic adenocarcinomas. We showed that both differences in mutational biases and differences in natural selection contribute to variation in the distribution of KRAS driver substitutions between tumor types. We identified specific KRAS driver substitutions that are more favored either across all tumor types or only in specific types of tumors. Finally, we found significant associations between the presence of KRAS substitutions that are more favored only in a specific type of tumor and worse clinical outcomes in patients with that tumor type.

January 10, 2016

Congratulations to Sarit on the birth of her son.

October 1, 2015

Adi Yannai and Olga (Oli) Oks join the lab.

September 1, 2015

Ruth’s Review “Mutation—The Engine of Evolution: Studying Mutation and Its Role in the Evolution of Bacteria” is out

July 10, 2015

Evgeni’s paper is out! Evgeni characterized the pangenomes of a large number of bacterial species. This allowed him to demonstrate that clonal pathogen lineages that are characterized by very low gene-sequence diversity and very low levels of horizontal gene gain evolve predominantly via gene loss. This results have clear implications for the study of clonal pathogens such as Mycobacterium tuberculosis and Yersina pestis.

July 1, 2015

Lab dinner to celebrate Sheli, Evgeni and Sarit’s birthdays. Happy birthday!

IMG_4477 IMG_4479


May 26, 2015

Wes’ paper is out! Wes looked at the frequency with which resistance alleles occurring within the house-keeping target genes of antibiotics segregate within natural bacterial populations. He found that some resistance alleles segregate at alarmingly high frequencies. In particular, one quinolone resistance allele that we have previously shown is adaptive when E. coli are starved segregates at extremely high frequencies particularly within the bodies of humans and other animals. These high segregation frequencies seem to be independent of antibiotic exposure. The paper just came out as an advanced online publication on the GBE website. It can be found here.

April 9, 2015

New paper published! In collaboration with Erin Reichenberger, Gail Rosen and Uri Hershberg from Drexel University we have shown that while there is a clear influence of phylogeny on nucleotide content in prokaryotes, environmental selection also seems to influence this trait. Our paper just came out as an advanced online publication on the GBE website. The paper can be found here.


March 10, 2015

Our first student to graduate! Wesley Field successfully defends his MSc. Thesis and leaves us to go work in Recombine in NYC. Best of luck!

February 25, 2015

Goodbye lunch for Wesley who is about to graduate. Also, celebrating Evgeni’s successful PhD Pre-exam,  Sheli being awarded the Jacobs excellence fellowship and Sarit being awarded a Postdoc fellowship.



February 23, 2015

Evgeni Successfully passes his PhD Pre-exam and is now officially a PhD student. Congratulations!

February 1, 2015

Dr. Sarit Avrani joins the lab as a Postdoctoral Fellow








February 1, 2015

Sheli is awarded the Jacobes Excellence Fellowship for her paper. Congratulations!

January 28, 2015

Dr. Sophia Katz is promoted to adjunct lecturer. Congratulations!

January 19, 2015

Wes gives his MSc thesis lecture.






November 15, 2014

Ashraf Al-Ashhab joins the lab









October 1, 2014

Michal Savkin joins the lab







May 26, 2014

Move to our new and permanent lab space begins. TECAN Freedom Evo Robot is installed in the new space.

May 21, 2014 – Sheli’s Wedding

Congratulations Sheli and Ben!

rikudim (353)May 8, 2014

Sheli Successfully defends her Pre-doc proposal and is now officially a PhD student. Congratulations Sheli!

Purim 2014, Beauty and the Geek


March 6, 2014

The lab’s first foray into Cancer evolution is published in PLoS Genetics

Ostrow SL, Barshir R, DeGregori J, Yeger-Lotem E and Hershberg R (2014) Cancer evolution is associated with pervasive positive selection on globally expressed genes. PLoS Genetics. 10(3): e1004239

February 25-26, 2014 – Faculty retreat, Nazareth, Israel

February 10-13, ILANIT conference, Eilat, Israel

February 3, 2014

Celebrating the acceptance of Sheli and Ruti’s paper to PLoS Genetics (To be published  March 6th)

January 1st, 2104

POGO-DB – a database of Pairwise-comparisons Of Genomes and conserved Orthologous genes is published in the Nucleic Acids Research Database Issue. This work was carried out in Collaboration with Yemin Lan, J. Calvin Morrison and Gail Rosen from Drexel University

November 14, 2013

1st paper from the lab published in PLoS Genetics!

Katz S and Hershberg R (2013) Elevated mutagenesis does not explain the increased frequency of antibiotic resistant mutants in starved aging colonies. PLoS Genetics. 9(11): e1003968.

March 1st, 2013

Evgeni Bolotin and Wesley Field join lab.








September 1st 2012

Sheli Ostrow joins lab





March 14, 2012

Presenting Dr. Sophie Katz.

We are proud to announce that Sophie Katz received her PhD today.














March 1st, 2012

A lab is born!